Paper of the Month - November, 2011

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Effect of switching antithrombin agents for primary angioplasty in acute myocardial infarction: the HORIZONS–SWITCH analysis

Dangas GD, Mehran R, Nikolsky E et al.; HORIZONS-AMI Trial Investigators.
Editor’s note: In this analysis of HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction [MI]) trial data, the authors examined the outcomes of switching from heparin to bivalirudin treatment in patients with ST-segment elevation MI (STEMI) who had received heparin prior to angiography. Consistent with the results of the main trial, the results of this analysis showed that bivalirudin is associated with a lower rate of bleeding events, and also lower rates of short- and long-term cardiac-related mortality. Thus, antithrombin switching appears to be a viable and safe option for STEMI patients who have previously been treated with heparin.