Rathore S, Terashima M, Matsuo H et al. Coron Artery Dis 2011;22:64–72.
In this study, the authors attempted to assess the prevalence of and quantify thin-cap fibroatheromas (TCFAs) and ruptured plaques in patients with coronary artery disease using optical coherence tomography (OCT). Higher incidences of TCFAs >3 mm in length and plaque rupture sites were found to be associated with ACS. OCT was deemed to be capable of identifying plaque characteristics, plaque rupture, TCFAs, erosions, and intracoronary thrombus presence in vivo.
Plaque composition is a key determinant of its propensity to rupture. Several imaging modalities can be used for the evaluation of coronary plaque characteristics. Intravascular optical coherence tomography (OCT) can identify microstructures and individual components of atheromatous plaques. The objective of the present study was to identify the frequency and number of thin-cap fibroatheromas (TCFAs) and ruptured plaque sites in patients presenting with stable angina (SA) and ACS (excluding those with ST-segment elevation ACS) using OCT.