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Prognosis

Goel K, Thomas RJ, Squires RW et al. Am Heart J 2011;161:590–7.

Although adiposity and reduced cardiorespiratory fitness are both associated with a higher rate of mortality in patients with coronary artery disease (CAD), few studies have examined the combination of these two factors. In this study, the authors combined markers of adiposity and a low level of cardiorespiratory fitness and explored their joint impact on mortality rate. They describe an independent association between central obesity plus reduced fitness and a high mortality rate among patients with previously established CAD.

 

The “obesity paradox” refers to the situation in which a lower mortality rate is observed among patients with coronary artery disease (CAD) and a high body mass index (BMI) than among CAD patients with a lower BMI. Beyond BMI, there are several other markers of adiposity and reduced cardiorespiratory fitness that have been individually associated with a greater risk of adverse cardiovascular outcomes.

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