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Medically Ill Patients

Rothberg MB, Lindenauer PK, Lahti M et al. J Hosp Med 2011;6:202–9.

In this work, the authors conducted a retrospective cohort study to assess available risk stratification tools and construct a suitable simple logistic regression model for venous thromboembolism (VTE). The findings indicate that 12 risk factors may be associated with the condition, although the risk of symptomatic VTE in general patients is low at <1%.


Among general medical patients, the incidence of venous thromboembolism (VTE) is approximately 1%; however, among patients within the highest risk group, the incidence may increase to 15%. Thromboprophylaxis with subcutaneous heparin is recommended for all medical patients at high risk for VTE. Patients with stroke, heart failure, chronic pulmonary disease, sepsis, and cancer are considered among those at high risk according to the American Association of Chest Physicians, and thromboprophylaxis is recommended in these individuals; however, there is neither validation of existing risk-stratification tools nor a specified risk-assessment procedure. Therefore, the aim of the present study was to construct a VTE risk-stratification model for hospitalized medical patients.

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