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Stent Thrombosis

Dangas GD, Caixeta A, Mehran R et al.  Circulation 2011;123:1745–56.

The present study investigated potential predictors and occurrence of thrombosis as a result of stent use as part of the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial. The findings suggest that thrombosis related to stent use is not a rare phenomenon in the 2 years following primary percutaneous coronary intervention in ST-segment elevation MI. It was also found that thrombosis appears to occur with similar frequency in cases of drug-eluting and bare-metal stent use, and with bivalirudin monotherapy versus heparin plus a glycoprotein platelet inhibitor.

 

Although the use of drug-eluting stents (DES) during percutaneous coronary intervention (PCI) in patients with stable coronary artery disease or acute coronary syndromes has reduced vessel restenosis, there is an increased risk of stent thrombosis. Therefore, the present study sought to evaluate the frequency and predictors of stent thrombosis occurring within the first 2 years after stent implantation in the setting of primary PCI in patients with ST-segment elevation myocardial infarction (STEMI).

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