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Diagnosis and Management

Khemasuwan D, Chae YK, Gupta S et al. Am J Med 2011;124:852–9.

In addition to lipid-lowering effects, statins have been shown to have anti-inflammatory and anti-thrombotic properties. A large, randomized, controlled trial suggested that, as a consequence of these pleiotropic effects, statins might prevent venous thrombosis in healthy subjects. However, the potential role of statins in the treatment or prophylaxis of venous thrombosis remains to be determined.


A recent large, randomized, controlled trial found evidence that that the anti-inflammatory and anti-thrombotic properties of statins might result in the prevention of venous thrombosis in healthy subjects [1]. In the current study, the authors tested the hypothesis that statins also have a role in preventing venous thrombosis in patients with established atherosclerosis.

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