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Post-Thrombotic Syndrome

Hull RD, Liang J, Townshend G.  Am J Med 2011;124:756–65.

This systematic review pooled data from nine studies comparing low-molecular-weight heparin (LMWH) with oral anticoagulation with regard to the incidence of post-thrombotic syndrome in patients with deep vein thrombosis. The authors found the incidence of post-thrombotic syndrome at ≥3 months to be lower in patients receiving LMWH.


Post-thrombotic syndrome may occur in up to 50% of patients with deep vein thrombosis (DVT) up to 2 years after the event. The HOME-LITE (Longitudinal Investigation of Thromboembolism Etiology Appendix A) study previously reported that patients receiving low-molecular-weight heparin (LMWH) had lower rates of leg ulcers and symptoms of post-thrombotic syndrome at 3 months compared with those receiving long-term warfarin [1].

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