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Lefèvre G, Lambert M, Bacri JL et al.  Lupus 2011;20:861–5.

The authors of the present study investigated the thrombosis rate in patients with pure obstetric antiphospholipid syndrome (APS). The study included women who were diagnosed with obstetric APS (either with fetal loss, preterm delivery between the 24th and 37th week of gestation, or first trimester miscarriages). The APS was also confirmed by persistent positive laboratory tests for antiphospholipid antibodies (aPL). All of the patients were taking physician-prescribed acetylsalicylic acid alone. The study showed that patients with pure obstetric APS are at a high risk of thrombosis compared with the general population and that women who are positive for multiple aPL autoantibodies and with antinuclear-antibody-associated or systemic-lupus-erythematosus-associated pure obstetric APS might be at a higher risk of thrombosis.


The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by venous and/or arterial thromboses and/or obstetric manifestations. Some patients develop only obstetric complications (obstetric APS), but data on the frequency of thrombotic events during the follow-up of these patients are scarce. Therefore, the present study estimated the thrombosis rate in pure obstetric patients with APS who were diagnosed according to the 2006 revised criteria [1]. The study included 32 obstetric APS patients according to the following clinical criteria:

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