Paper of the Month - November, 2011

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Androgen receptor expression and breast cancer survival in postmenopausal women.

Hu R, Dawood S, Holmes MD et al.
The androgen receptor (AR) is known to be commonly expressed in breast cancer cells, but its role as a prognostic factor is unclear (see J Surg Oncol 2008;98:551–8, reviewed in CML – Breast Cancer 2009;21:27–9). The present authors investigated the prognostic value of the AR using data from the NHS (Nurse’s Health Study). The NHS is a prospective cohort of 121 700 female registered nurses from the US aged 30–55 years who completed a mailed health questionnaire in 1976, with follow-up questionnaires sent out every 2 years between 1976 and December 2007. Intervening deaths were ascertained by report from next of kin, postal authorities, or the US National Death Index. For the present investigation, the selected patients were postmenopausal women diagnosed with stage I–III breast cancer between 1976 and August 1997, in whom tissue microarrays from breast cancer tissue blocks could be obtained.


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