Cooper-DeHoff RM, Gong Y, Handberg EM et al.
University of Florida, Gainesville, FL, USA.
Editor’s note: In 1993, the 5th report of the Joint National Committee (JNC) recommended a blood pressure (BP) target of <130/85 mmHg for systolic BP (SBP) and diastolic BP (DBP) in hypertensive patients with diabetes (Arch Intern Med 1993;153:154–83). This recommendation was based on the results of the HOT (Hypertension Optimal Treatment) study, which suggested a lower incidence of adverse cardiovascular (CV) outcomes in those with tighter BP control (Lancet 1998;551:1755–62). More recently, further support came from the UKPDS (UK Prospective Diabetes Study), which showed a reduction in macrovascular and microvascular outcomes in patients with diabetes and hypertension who had been randomized to tight BP control (<150/85 mmHg; BMJ 1998;317:703–13, BMJ 2000;321:412–9).