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Kajander S, Joutsiniemi E, Saraste M et al.

Turku Positron Emission Tomography Centre, Turku, Finland.

 Circulation 2010;122:603–13.

Editor’s note: Numerous imaging modalities are employed to assess the presence and severity of coronary artery disease (CAD) and its impact on the heart. Computed tomography (CT) is frequently used to characterize coronary arterial stenosis. However, the impact of a given stenosis on myocardial perfusion in the region of supply by the partially occluded artery varies from lesion to lesion and from patient to patient for a variety of reasons, including the presence, distribution, and extent of collateral vessels; the nature of the native arterial circulation; and the extent of preservation of microcirculatory functional integrity. Accordingly, assessment of myocardial perfusion provides additional information regarding the functional importance of a given magnitude of coronary arterial stenosis. Unfortunately, estimates of stenosis even with sophisticated techniques such as CT angiography (CTA) are not necessarily definitively accurate.

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