de Boer RA, Doehner W, van der Horst IC et al.
The University of Groningen, Groningen, The Netherlands.
Am J Cardiol 2010;106:78–86.e1.
Editor’s note: The present authors sought to determine the extent to which the use of β-blockers in elderly patients with diabetes and heart failure led to benefits that are comparable to those seen with the use of β-blockers in otherwise comparable patients without diabetes. The study was predicated on the well-established beneficial effects of β-blockers in younger patients with heart failure manifested by systolic dysfunction (JAMA 2007;297:1233–40). It is well known that diabetes is associated with a high incidence and prevalence of heart failure, that the outcomes with heart failure are worse in patients who have diabetes compared with those who do not have diabetes, and that diabetes is a common comorbidity in patients with heart failure, as reviewed in this article.