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Peritoneal Spread of Colorectal Cancer: Prevention and Treatment

WP Ceelen, MD, PhD

With a worldwide mortality rate of over half a million deaths per year, colorectal cancer (CRC) remains a major cause of cancer-related mortality [1]. Malignant CRC ultimately causes death by distant organ invasion; thus, identification of the molecular mechanisms underlying hematogenous and lymphatic metastasis is the subject of intensive research activity [2]. In parallel, the introduction of targeted biological agents has resulted in considerable survival prolongation in patients with metastatic CRC (mCRC) [3].

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