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Predictive Markers

Arcaroli JJ, Touban BM, Tan AC et al.

University of Colorado, Denver, CO, USA.

 Clin Cancer Res 2010;16:4165–77.

Editor’s note: In the current study, the authors investigated the efficacy of saracatinib, a Src kinase inhibitor, in colorectal cancer (CRC). They tested a new human CRC explant model; 10 resected tumors from patients with CRC were explanted directly from surgery into mice. The authors consider this to be a better reflection of human malignancy than known xenograft models.

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