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Guastadisegni C, Colafranceschi M, Ottini L et al.

Istituto Superiore di Sanità, Rome, Italy.

 Eur J Cancer 2010;46:2788–98.

Editor’s note: The prognostic value of microsatellite instability (MSI) in colorectal cancer (CRC) has already been established: CRC patients with MSI have a better prognosis than those without MSI (J Clin Oncol 2005;23:609–18). In addition, CRC patients with MSI may have a reduced response to 5-fluorouracil (5-FU)-based chemotherapy (N Engl J Med 2003;349:247–57). In the present study, Guastadisegni et al. conducted a systematic review of published studies to estimate the prognostic and predictive significance of the MSI phenotype in CRC.

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