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Lung Function Assessment

Stanojevic S, Stocks J, Bountziouka V et al.

Hospital for Sick Children, Toronto, ON, Canada.

 J Cyst Fibros 2013 Dec 12; Epub ahead of print.

Paul Robinson’s review: Recent work has produced the influential Global Lung Function Initiative-2012 (GLI-2012) multi-ethnic, all-age reference equations, which have been endorsed by all respiratory societies as the new gold standard for spirometry (Eur Respir J 2012;40:1324–43). Manufacturers will soon be implementing these reference equations in commercial spirometry equipment, but the impact of this switch for cystic fibrosis (CF) patients is unclear. The authors of the current study sought to describe this impact.

In an analysis of annual review data submitted to the UK CF Trust Registry over a 5-year period (2007–2011; >26000 observations), values for spirometry outcomes (percent of predicted forced expiratory volume in 1 s [FEV1], percent of predicted forced vital capacity [FVC], and FEV1/FVC) were calculated with the use of the GLI-2012 equations and compared with values calculated using other reference equations in common use, Wang–Hankinson (currently used in North America) and Knudson (currently used in the UK). Children aged <6 years were excluded, as neither Wang–Hankinson nor Knudson equations can be applied to subjects below this age.

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