Paper of the Month - July, 2011

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The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.

Kapoor A, Goldberg MS, Cumberland LK et al.
Both genetic and epigenetic changes are involved in the development of cancer. Genetic changes are those in the DNA sequence and can be inherited or acquired. Epigenetic changes are inheritable changes in phenotype or gene expression resulting from causes other than DNA-sequence changes. Histones, the core proteins around which DNA strands are wound, are implicated in gene regulation. Histone variants replace conventional histones within the nucleosome and confer unique biological functions to the chromatin. In this study, the role of histone variants in promoting melanoma formation is examined.