Paper of the Month - April, 2013

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Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles.

Borkowski AW, Park K, Uchida Y et al.
Jürgen Schauber’s review: In order to mount an appropriate immune response to skin injury, cells that reside in the skin are equipped with sensors that can detect tissue damage. Some of these innate immune receptors belong to the family of the Toll-like receptors (TLRs); for example, TLR-9 detects double-stranded DNA released from damaged cells.


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