McKay KM, Sambrano BL, Fox PS et al.
The University of Alabama at Birmingham, Birmingham, AL, USA.
Br J Dermatol 2013;169:549–54.
Jürgen Schauber’s review: Basal cell carcinoma (BCC) is the most common malignancy in the Caucasian population, and the incidence of BCC is rising dramatically. Hence, BCCs are prominent drivers of healthcare costs, and cause significant morbidity. Several topical, noninvasive treatments have been introduced for superficial BCC (sBCC), with topical imiquimod being one such effective alternative to surgical excision. However, these topical therapies only cure superficial tumors, and there are currently no uniform histological definitions of sBCC. Recurring tumors or deeply penetrating BCCs cannot be treated by topical agents but must be excised surgically. Therefore, a definition of BCCs based on tumor thickness may help guide treatment decisions.