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Genetics

Segura S, Rozas-Muñoz E, Toll A et al.

Hospital del Mar, Barcelona, Spain.

 Br J Dermatol 2013;169:106–14. 

Jürgen Schauber’s review: Chronic inflammation of mucosal tissues increases the risk of malignant transformation. Furthermore, squamous cell carcinomas that arise in chronically inflamed tissue have increased metastatic potential. Lichen planus is a common, chronic, inflammatory, mucocutaneous condition that frequently involves the oral mucosa. However, the issue of malignant transformation of oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) is controversial. The World Health Organization classifies OLP as a premalignant condition that can potentially progress to OSCC; however, the exact mechanisms are not completely clear. Furthermore, tissue markers for identifying this malignant transformation have not yet been established.

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