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Childhood Obesity and Diabetes

MARIA R SIGNORINO1 AND WILLIAM E WINTER2

Given the rising prevalences of obesity and type 2 diabetes in children, there is concern that the present generation of children may, due to accelerated cardiovascular disease, experience a reduced lifespan compared with their parents’ generation [1]. Additionally, the healthcare costs of young adults with type 2 diabetes are increasing dramatically [2]. The overlap between obesity, diabetes, and atherosclerosis involves the metabolic syndrome [3], of which the major pathophysiology is insulin resistance (Figure 1) [4,5]. Because of the high frequency of premature coronary, carotid, and peripheral vascular disease in adulthood, the term metabolic syndrome is rapidly becoming known as the “cardiometabolic syndrome” [6].

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