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Genetic Associations with Type 1 Diabetes: What Do We Know?

Hakon Hakonarson, MD, PhD, and Struan FA Grant, PhD

Diabetes impacts approximately 200 million people worldwide [1], with microvascular and cardiovascular disease being the primary complications. Approximately 10% of all cases suffer from type 1 diabetes, with an approximate 3% increase in the incidence of type 1 diabetes globally per year occurring at present [2]. It is expected that the incidence will be 40% higher in 2010 than it was in 1998 [3].

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