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Pathophysiology

Vittone F, Liberman A, Vasic D et al.

University of Ulm, Ulm, Germany.

 Diabetologia 2012;55:2267–75.

Editor’s note: In clinical use, dipeptidyl peptidase-4 inhibitors reduce glycated hemoglobin levels by increasing plasma concentrations of glucagon-like peptide-1 (GLP-1). In turn, GLP-1 may have direct effects on the cardiovascular system. In this elegant study, the authors compared sitagliptin and placebo in mice fed a high-fat diet and examined plaque macrophage contents. Compared with placebo, sitagliptin reduced plaque macrophage infiltration and plaque matrix metalloproteinase-9 (MMP-9) concentrations in these mice. Plaque levels of collagen, which is thought to stabilize plaques, increased significantly.

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