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Volume 31 Issue 4

Paper of the Month

A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn's disease.

Sands BE, Katz S, Wolf DC et al.
Mount Sinai School of Medicine, New York, NY, USA.
Gut 2012 Jul 3; Epub ahead of print.
Editor's note: Granulocyte and monocytes contribute to the pathogenesis of inflammatory bowel disease (IBD) by secreting proteases and proinflammatory cytokines, including tumor necrosis factor (TNF), interleukin-1β (IL-1β), and IL-6 that induce and maintain mucosal inflammation. Apheresis can selectively deplete activated granulocytes and monocytes.
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