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Crohn’s Disease of the Ileal Pouch

Lei Lian, MD1,2, and Bo Shen, MD1

Since the 1980s, restorative proctocolectomy (RPC) with ileal pouch–anal anastomosis (IPAA) has become the surgical procedure of choice for patients with ulcerative colitis (UC) that is refractory to medical treatment or UC-associated dysplasia or cancer. Approximately 30% of patients with UC eventually require surgery [1]. Much progress in the field of medical therapy for UC has been made over the last decade, particularly with the introduction of anti-tumor necrosis factor-α (TNF-α) agents. However, whether the use of immunomodulators or anti-TNF-α agents can alter the natural history of UC, particularly the requirement for colectomy, remains to be determined.

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