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Genetic Defects of the GH–IGF Axis Associated with GH Insensitivity

Katie Woods, MBBS, MD


Genetic growth hormone (GH) insensitivity (GHI), also known as insulin-like growth factor-1 (IGF-1) deficiency, is characterized by impaired linear growth in association with reduced IGF-1 and elevated (or at least normal) GH secretion. In recent years, the identification and characterization of subjects with this condition has provided many insights into the functioning of the GH–IGF-1 axis in humans and the factors controlling human growth.

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