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Treatment of Severe IGF-1 Deficiency with Recombinant Human IGF-1 (Mecasermin)

Philippe F Backeljauw, MD1 and Steven D Chernausek, MD2

Growth hormone (GH) is widely used to treat short stature resulting from a variety of conditions, including GH deficiency, Turner syndrome, and chronic renal failure. Until 2005, GH was the only medication available for growth promotion in children to be approved by the US Food and Drug Administration (FDA). Since then, recombinant human insulin-like growth factor-1 (IGF-1; mecasermin) has also been approved for the treatment of short stature resulting from severe primary IGF-1 deficiency.

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