Kumar SS, Ayuk J, Murray RD.
Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Adv Ther 2009;26:383–403.
Editor’s note: The prevalence of acromegaly is reported to be approximately 40–60 cases per million people, with an annual incidence rate of 3–4 per million people (Pituitary 1999;2:29–31). In over 95% of patients with acromegaly, the etiology is a pituitary tumor (N Engl J Med 2006;355:2558–73). Mortality rate is increased predominatly due to cardiovascular, cerebro-vascular, and respiratory diseases. Therapeutic interventions aim to reduce growth hormone (GH) levels to <2.5 µg/L (5 mU/L).