Tzschoppe A, Struwe E, Blessing H et al.
University of Erlangen–Nuremberg, Erlangen, Germany.
Pediatr Res 2009;65:647–53.
Editor’s note: Intrauterine growth restriction (IUGR) is associated with an increased risk for short stature and diseases in adulthood that are thought to be due to fetal programming (the Barker hypothesis). The current authors hypothesized that post natal growth in infants who have IUGR may be influenced by the placental endocrine systems. In this prospective study, the investigators determined the placental expression of the genes that encode insulin-like growth factor-binding protein-1 (IGFBP-1), leptin (LEP), and 11β-hydroxysteroid dehydrogenase type 2(11β-HSD2) in 14 infants with IUGR and 15 healthy newborns.