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IGF-1

Edouard T, Grünenwald S, Gennero I et al.

Hôpital des Enfants, Toulouse, France.

 Eur J Endocrinol 2009;161:43–50.

Editor’s note: The recent resurgence of interest in severe primary insulin-like growth factor (IGF) deficiency since the product license was awarded to recombinant human IGF-1 (mecasermin) has prompted many pediatric endocrine units to review the phenotypes and endocrine profiles of the short stature patients who have apparently normal growth hormone (GH) status yet significantly low serum IGF-1 levels. While the vast majority of previously recognized GH-resistant patients have matched the reported phenotypes of Laron dwarfism and equivalent cases, the so far extremely rare heterozygous/autosomal dominant phenotype is seldom apparent, but must be presumed to exist in greater numbers and merits careful search within the short stature population.

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