Effects of Growth Hormone on Visceral Fat and Insulin Sensitivity

David M Cook and Kevin CJ YUEN
Oregon Health and Science University, Portland, OR, USA

Obesity is characterized by marked decreases of both spontaneous and stimulated growth hormone (GH) secretion [1], variable levels of circulating insulin-like growth factor I (IGF-I) [2,3], and insulin resistance [4]. Correspondingly, GH-deficient adults are commonly obese and have similar clinical features to obese subjects, including abnormalities of body composition such as increased abdominal and visceral fat mass, glucose intolerance, and insulin resistance [5].
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