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Soiffer RJ, Lerademacher J, Ho V et al.

Dana-Farber Cancer Institute, Boston, MA, USA.

 Blood 2011;117:6963–70.

Editor’s note: Reduced-intensity conditioning in allogeneic transplants is increasing in frequency. It allows transplants to be conducted with reduced toxicity, and extends the option of transplant to older or less fit patients. The cytoreductive effects of conditioning chemotherapy are insufficient to eradicate malignancy and the success of the transplant relies on a graft-versus-tumor effect. Many centers use T cell depletion using alemtuzumab or antithymocyte globulin (ATG) to diminish graft-versus-host disease (GvHD) and aid engraftment, but the effect on the therapeutic outcome of the graft is not well known.

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