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DNA Methylation Abnormalities in Mature B-cell Lymphoid Neoplasms

Mark Glenn, Andrew Duckworth, and Nagesh Kalakonda

Epigenetics is the study of heritable changes in gene expression that occur independently of alterations in DNA sequence. Precision and fine-tuning of protein expression, post-translational modifications, and alternative splicing are essential for the integrity of normal cellular development and differentiation. Fundamental processes such as DNA methylation, histone modifications, and microRNA expression cooperate and coordinate changes in chromatin topology, and ensure programmed gene expression (

  • Figure 1
). It is now abundantly clear that subversion of epigenetic phenomena is a critical ingredient for oncogenic transformation. Aberrations in DNA methylation, in particular, are well documented in all cancers [1–4]. In this review, we focus on the perturbation of DNA methylation in mature B lymphoid malignancies.

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