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Chronic Leukemia

Such E, Germing U, Malcovati L et al.

The Spanish MDS cooperative group.

 Blood 2013;121:3005–15.

Rob Sellar’s review: Chronic myelo-monocytic leukemia (CMML) has a highly variable clinical course with large differences in overall survival (OS) and risk of transformation to acute myeloid leukemia (AML). Although some prognostic factors such as cytogenetics have been identified, prognostic scoring systems have been limited by the small patient numbers used to derive the systems, the inclusion of patients without CMML as defined by World Health Organization (WHO) criteria, and the inability to predict the risk of transformation to AML.

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