Li ZM, Ding ZP, Luo QQ et al.
Shanghai Jiaotong University, Shanghai, People’s Republic of China.
Philip Linden’s review: The current American Joint Commission on Cancer/Union for International Cancer Control 7th edition staging system for NSCLC does not incorporate either the number of involved nodes or the ratio of involved nodes into staging. However, for other cancers, such as esophageal cancer, the number of involved nodes has recently been incorporated into the staging system. The current authors reviewed 206 stage II NSCLC patients who underwent anatomical resection in Shanghai, People’s Republic of China, between 1999 and 2009. Only patients who had ≥10 lymph nodes dissected were included in the analysis. Univariate and multivariate survival analyses were performed incorporating the following variables: pattern of nodal involvement (peripheral [level 12–14] or central [level 10–11]), ratio of positive lymph nodes to total lymph nodes sampled (≤0.15 or >0.15), number of involved nodes, age, gender, smoking history, type of resection, visceral pleural involvement, lymphovascular invasion, and tumor size.