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Childhood Tubulointerstitial Nephritis and Uveitis Syndrome


Ville Saarela, MD, PhD1, Matti Nuutinen, MD, PhD1, and Timo Jahnukainen, MD, PhD2

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a relatively rare condition affecting both children and adults. There are approximately 250 reported cases in the literature, and >50% of patients are aged <20 years [1,2]. In TINU syndrome, intraocular inflammation coexists with TIN. TIN typically causes tubular dysfunction leading to low-molecular-weight proteinuria and glucosuria, and in some cases generalized renal insufficiency. The renal dysfunction is usually reversible, although in approximately 10% of patients it may persist [2,3].

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