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Corneal Collagen Crosslinking

David PS O’Brart, MD, FRCS, FRCOphth

Keratoconus is a degenerative, non-inflammatory disorder, characterized by central/paracentral corneal stromal thinning. The ensuing conical ectasia results in irregular astigmatism causing reduced vision and monocular polyopia [1–3]. It is typically bilateral but often asymmetrical. Onset is usually around puberty, with the condition progressing until the third or fourth decade of life when it usually arrests. It affects approximately one in 2000 individuals, occurring in all ethnic groups, and equally affects males and females [1–3]. Quality of life (QoL) analysis indicates that its magnitude of public health impact is disproportionate to its prevalence, with scores of QoL impairment similar to grade 3–4 age-related macular degeneration [4].

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