Paper of the Month - December, 2011

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Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel–Lindau disease and HIF-2α gain-of-function mutation.

Formenti F, Beer PA, Croft QP et al.
Editor’s note: Hypoxia-inducible factor-1α (HIF-1α) and HIF-2α regulate several key aspects of cellular adaptation to hypoxia, with control of hundreds of genes involved in cell metabolism, cell growth, angiogenesis, and matrix remodeling, among other things.


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