A pulmonary hypertension model induced by continuous pulmonary air embolization.
Zhou X, Wang D, Castro CY et al.
Exploring right ventricular (RV) responses to pulmonary hypertension (PH) and the pathobiological changes in the pulmonary arteries (PAs) requires that we have good large animal models of PA hypertension (PAH). To date, all models have their problems, including a high attrition rate, only modest transient elevation of pulmonary pressures, marked inflammatory response not seen in clinical PAH, and/or modest vascular changes. To overcome this, Zhou et al. intubated four sheep and slowly infused small volumes of filtered air into the main PAs over a period of 8 weeks. They were able to demonstrate the induction of moderate PH (mean PA pressure 35 mmHg), RV hypertrophy, and widespread intimal and medial hypertrophy in the pre-acinar and intra-acinar arteries, and the PH persisted after cessation of air injection for at least 1 week.