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Pathology and Epidemiology

D’Alto M, Mahadevan VS.

Second University of Naples, Naples, Italy.

 Eur Respir Rev 2012;21:328–37.

Editor’s note: This is a thorough review of pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH), summarizing the demographics, pathophysiology, comorbidities, and treatment of the condition; however, the authors’ most appreciable contributions concern the general management and treatment of CHD-PAH with specific therapies. There are interesting sections on certain subgroups of CHD-PAH, patients with Down syndrome, and patients with Eisenmenger syndrome. It is possible to summarize the main messages as follows:

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