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Osteoarthritis and Osteoporosis

Reid IR, Bolland MJ, Grey A.

University of Auckland, Auckland, New Zealand.

 Lancet 2014;383:146–55.

Lucía Silva’s review: Vitamin D has long been regarded as a fundamental part of the prevention and treatment of osteoporosis. Nevertheless, observational studies have shown inconsistent associations between bone mineral density (BMD) and vitamin D status, and the optimum concentration of 25-hydroxyvitamin D (25[OH]D) for maintaining skeletal health remains uncertain. The authors of this systematic review aimed to address these issues by analyzing all randomized controlled trials of cholecalciferol or ergocalciferol that included BMD data in adults without other disorders likely to affect bone or calcium metabolism.

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