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Systemic Lupus Erythematosus

Ruiz-Irastorza G, Danza A, Perales I et al.

Hospital Universitario Cruces, Barakaldo, Spain.

 Autoimmun Rev 2014;13:206–14.

Gerard Espinosa’s review: Prednisone is one of the cornerstones of treatment for patients with lupus nephritis (LN). Guidelines on the diagnosis and management of renal involvement in systemic lupus erythematosus have recently been published by a number of scientific societies. All of them recommend the combination of prednisone and immunosuppressants for the induction regimen of patients with proliferative and membranous LN. However, there is no strong evidence on the optimal initial dose of prednisone. Notably, European League Against Rheumatism guidelines recommend induction treatment with intravenous pulses of methylprednisolone in all patients, followed by doses of 0.5 mg/kg/day (instead of 1 mg/kg/day; Ann Rheum Dis 2012;71:1771–82).

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