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Editor’s note: The purpose of the current study was to assess the efficacy of vinblastine to treat transitional cell carcinoma (TCC) of the bladder in dogs. Vinblastine has been widely used for the treatment of mast cell tumours, but its use in the treatment of TCC has not been assessed. However, in experimental studies, vinblastine has shown antiproliferative effects on TCC cells in vitro.