Manchester AC, Hill S, Sabatino B et al.
Cornell University, Ithaca, NY, USA.
J Vet Intern Med 2013;27:56–61.
Patricia Ibarrola’s review: Granulomatous colitis is a well-described disease in young Boxer dogs. It is characterised by large intestinal signs and granulomatous inflammation of the colonic mucosa, lamina propria, and submucosa with periodic acid–Schiff (PAS)-positive macrophages. Invasive Escherichia coli are involved in the pathogenesis of this disease and it can be successfully treated with antimicrobials (fluoroquinolones). It has been reported sporadically in other breeds. In this study, six French Bulldogs that were presented to different referral centres in the US were investigated for large intestinal signs. Colonoscopy was performed in all dogs and biopsies taken from the colon. These were submitted for histopathological examination, and additional colonic samples were tested for bacterial colonisation using 16S ribosomal RNA probes for eubacteria and E coli by means of fluorescent in situ hybridization (FISH).