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Meurs KM, Stern JA, Reina-Doreste Y et al.

North Carolina State University, Raleigh, NC, USA.

 J Vet Intern Med 2014;28:1214–20.

Sarah Smith’s review: This large, prospective, longitudinal study was designed to evaluate the natural history of what is commonly known as “Boxer cardiomyopathy” or arrythmogenic right ventricular cardiomyopathy (ARVC); the first author is a well-known authority in the fields of both cardiomyopathy and genetics.

A population of 551 Boxer dogs aged >8years was screened for ARVC and re-evaluated, where possible, annually. Tests included echocardiography, 24-h ambulatory electrocardiography, and genotyping for the striatin gene deletion that has previously been shown to be associated with the disease (Hum Genet 2010;128:315–24). Dogs with serious systemic disease, or congenital or other acquired diseases, were excluded. Anti-arrhythmia treatment was at the discretion of each dog’s clinician and was not evaluated; some dogs received no treatment.

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