0 rating

Neurology

Bersan E, Volk HA, Ros C et al.

Animal Health Trust, Newmarket, UK.

 Vet Rec 2014;175:247.

Mark Lowrie’s review: Phenobarbitone (PB) is an anti-epileptic medication licensed for dogs with idiopathic epilepsy. Sedation, ataxia, polyphagia, polyuria/polydipsia, and body-weight gain are common dose-related adverse effects that generally improve or resolve after serum concentrations of PB reach a steady state. Idiosyncratic reactions related to PB are rare but include superficial necrolytic dermatitis, pancreatitis, haematological abnormalities, and dyskinesia. PB-induced haematological abnormalities (PBIHA) such as anaemia, thrombocytopenia, and/or neutropenia have been reported in a small number of dogs.

The current authors document clinical presentations and pathological abnormalities of PBIHA in dogs receiving PB. In addition, the prevalence and risk factors for developing PBIHA among the entire population of idiopathic epileptic dogs was evaluated. Dogs with idiopathic epilepsy receiving PB as monotherapy or polytherapy were included. Dogs that received medications other than PB that have been reported to cause haematological abnormalities, and dogs with concurrent medical disorders that could result in haematological abnormalities, were excluded from the study.

Return to top

RELATED ARTICLES

The Management of Pharmacologically Refractory Epilepsy
Evelien Carrette, MSc, PhDs, Kristl Vonck, MD, PhD, and Paul Boon, MD, PhD.
CML Neurology
Deep Brain Stimulation for the Treatment of Epilepsy
Jyoti Pillai, MD1 and Michael R Sperling, MD2
CML Neurology
Advances in the Management of Idiopathic Epilepsy in Dogs
Mark Lowrie, MA, VetMB, MVM, DipECVN, MRCVS
Companion Animals
Neurovascular Disorders
CML Neurology
Epilepsy
CML Neurology
Pathogenesis
CML Multiple Sclerosis

LATEST ARTICLES

Our most popular articles