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GENETICS

Paik J, Fierce Y, Treuting PM et al. J Nutr 2013;143:1240–7.

This study demonstrates the concept of an “inflammatory trigger” in IBD, secondary to high dietary fat on a background of genetic susceptibility.

 

Increasing evidence implicates the pro-inflammatory potential of fat. Epidemiological studies have shown that key environmental influences in IBD may be obesity in Crohn’s disease and high 6-n-polyunsaturated fat intake in ulcerative colitis. Here, the authors demonstrate the role of a high-fat diet in a susceptible mouse colitis strain, the multidrug resistance 1-deficient (Mdr1a–/–) mouse. This mouse model develops spontaneous colitis when maintained in specific pathogen-free environment.

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