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Therapeutics Research

Mak A, Cheung MW, Cheak AA et al.

 Rheumatology (Oxford) 2010;49:281–8.

Antiphospolipid syndrome (APS) is characterized by recurrent pregnancy loss associated with serological features of persistent elevation of antiphospholipid (aPL) antibodies. A meta-analysis of five trials shows that combined treatment with heparin and aspirin is superior in terms of achieving more live births and reducing the number of pregnancy complications such as pre-eclampsia.

 

The present investigators performed a meta-analysis of five randomized controlled trials to assess the efficacy of a combination of heparin and aspirin versus aspirin alone in patients with recurrent pregnancy loss and who were positive for antiphospholipid antibodies.

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