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Pathogenesis

Gordon A, Greenfield EM, Eastell R et al. J Orthop Res 2010;28:1127–35.

The different patterns of innate cytokine gene expression in response to pro-inflammatory stimuli between osteolysis-susceptible patients and non-susceptible patients after total hip arthroplasty may lead to the variation in osteolysis susceptibility that is observed between individuals in the clinic.

 

The major clinical challenge that limits prosthesis survival after total hip arthroplasty (THA) is wear-related osteolysis, which can lead to aseptic loosening. Although previous clinical studies have shown increased serum levels of pro-inflammatory cytokines in patients with active osteolysis compared with healthy or osteoarthritis control subjects [1,2], it remains unknown whether osteolysis-susceptible patients post-THA display different quantitative innate cytokine responses to particulate debris compared with individuals who do not display susceptibility to osteolysis.

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