Paper of the Month - May, 2011

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Emerging invasive zygomycosis in a tertiary care center: epidemiology and associated risk factors

Ambrosioni J, Bouchuiguir-Wafa K, Garbino J.
The purpose of this retrospective study was to describe the epidemiological factors associated with an increased incidence of invasive zygomycosis at a single institution. Nineteen cases of invasive zygomycosis were identified during 1989–2008. Sixteen of these cases (84%) were diagnosed during 2003–2008 following the introduction of voriconazole and caspofungin in 2003. Although the number of cases of invasive zygomycosis seen in this later period increased from that seen in the earlier period of 1989–2003 (p<0.001), relatively little change in the total number of positive cultures was noted. The increased incidence of invasive zygomycosis was related to greater usage of the antifungal agents caspofungin and voriconazole and an increased number of immunosuppressed patients.


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